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this population (Blanchard et al., 2002). These ndings suggest that those individuals with psychological distress are not exactly the same group with a history of abuse. These ndings have important implications with respect to treatment. General Comments We have summarized the literature to date on IBS, with a speci c focus on psychosocial factors of assessment. When diagnosing and assessing IBS, it is important to consider, in addition to de nitional and epidemiological issues, the possible role of psychological distress, treatment-seeking factors, and the role of stress and early abuse in the manifestation of IBS symptoms. Such factors may be important to address in treatment, which we will discuss later in this chapter. Now, we turn to a possible developmental precursor to IBS recurrent abdominal pain.

Heart Rate (BPM)

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chemical gradient that would, in the absence of any other force, eventually result in a similar concentration of the ions on both sides of the membrane (i.e. diffusion is taking place). On the other hand, there is also an electrical gradient within the cell as a result of the difference in charge between the sodium cations and larger anionic units (such as cellular proteins) that are too big to pass out of the cell. As a result of these two opposing forces ions ow in both directions across the membrane, eventually achieving equilibrium. We term this the equilibrium potential. When we consider the movement of ions into and out of cells in this context we really only need to consider sodium (Na+), potassium (K+ ), chloride (Cl ), and calcium (Ca2+ ). Each of these ions will of course achieve its own equilibrium potential and summed together they amount to the resting potential of the cell. This can be thought of as the force required to maintain the status quo and it is usually measured as having a value of around 65 millivolts. This is the cell s background state if you like, and if the cell is involved in electrical signal transmission, as either a sender or a receiver, we will be able to record a deviation from that state.

properties of sampling distributions from sample data that have more general applications. In this parametric emphasis, the chapter follows earlier publications such as Cliff (1993, 1996a, 1996b), Long (1999), and Long and Cliff (1997).